Set in a world where humans were at odds with the other races until a mysterious pandemic has started to turn the majority of mankind into savage, animalistic creatures called Ferals. Because of this, the Royal Sisters made a walled city where many Equestrians and selected non-infected humans would be safe from the Ferals. While the rest of the world around it seemingly decays.

Years later 16 year old human named Spike Clawson is having a miserable life, from the loss his parents to the outbreak when he was young, constantly being mistreated by those around him because of his race, and lives alone in a rotting apartment.

Having enough of the unjust treatment, Spike sets out to find the last place on the planet where he can live happily without being treated like a plague. Accompanying him is a group of pony girls who while they've never been there for Spike in person seek to make it up to him and join him on his quest to show not every pony in Canterlot hated him for what he is.