Oh, great, another peculiar and perilous pony plague! This time, the outbreak in Ponyville is so bad that it was quarantined from the rest of Equestria. Nopony knows what this mysterious disease is, or how to cure it. The only thing that anypony knows is A) There is no known cure. B) It is extremely contagious. C) If you come down with it, you will die within five days. D) The only way to spot it is an unnatural craving for canned tomato soup. E) It is spread by a single touch.
When Twilight's friend Lyra comes down with the disease, the race is on to find a cure, before Lyra spreads the disease to anypony else.

(Cover art by BurritoMilk)