Thomas Nye is not a hero. He is apathetic, sarcastic, and full of contempt for the world. He finds this ironic as the world has now been, essentially, blown up. After a botched attempt at CERN to do 'something', something that the living scientific community will not disclose, a group of remaining humans, and distrustful ponies, must work together to figure out how to prevent the same fate befalling Equestria and all surrounding nations, or it'll be Game Over for everybody.