While on the hunt for Dio, Jojo's team come across a young girl who holds a golden object. When they try to ask her were she got it from she uses a strange power and cast them down into an abyss. When they awoke they find out that they have all been turn into ponies and in an entire new world. Now they are on a quest to return to their own world and kill Dio before Jotaro's mother dies.

Note: You should have some knowledge of Jojo's universe from book one till book four

My Little Pony: Friendship is Magic is owned by Hub Network
Jojo's Bizarre Adventure is owned by Hirohiko Araki