Applebloom, Sweetie Belle, and Scootaloo have always been there for one another. But, after earning their cutie marks, finding jobs to handle, and living their own lives, it seems the Cutie Mark Crusaders have truly split up. After years of little communication between the three, their former friendship is nearly at a loss.

Until disaster strikes.

Something strange is happening across Equestria, and as far as they know, the three former crusaders are the only ones unaffected by what could be some sort of spell. Unable to find answers, the three must try to band together once more and learn what's going on. But with ponies after them at every turn, will they be able to succeed? And will rising tensions among the three keep them from their task?