Almost everything in creation can be changed if you try hard enough. New nations will rise as the old ones fall and crumble to dust, and yet though all the change, life will endure. Even life is not unsusceptible to change though, and the passage of time may warp even this into new and terrible shapes.
Change can be good, and yet it can just as easily be terrible, paving the way for war and tyrants to run unopposed across whatever world they have found themselves on.
There is one thing however that can never change, one thing that has been proved time and time again to be immortal, no matter how hard you try. You can change life, the passage of time will advance, you can tear down nations and force up new flags.

You Can’t Change Nature