Henrietta or "Henry" Trotter is a unicorn, a breed of pony that can perform magic while her best friend is a teenage girl who learns that she is part of the Homo Magica race, humans who also have magical abilities. Then one day while out running, the two find an ancient amulet that forever changes both of their lives. Upon waking up, they realize that they can communicate with each other while growing from Mal's forehead is a mysterious bump. To save her from the wrath of the humans who fear their new powers, Bumblehoof, headmare of Princess Celestia's School for Gifted Unicorns, takes both filly and girl under her wing, bringing the two into the once secret world of Equestria. This only happens to be the start of the adventure of a lifetime. As if anypony could handle the all-mighty powers of a living god.