While adventuring out in the Everfree Forest to visit Zecora, the CMC stumble upon a poisonous plant that almost puts them in serious danger! Luckily Zecora was able to interferee before it was to late, but the poison had already put them to sleep, forcing the zebra to take them to her house to recover and reveal a mysterious prophecy, which happens overnight as an invisible wave sweeps over Ponyville and changes the cutie marks of the entire town. When the CMC wake up, they find their sisters missing and the entire town in chaos! Rushing back to Zecora, the four must adventure out into the depths of the forest to find a cure for this curse! What will they find, will they make it back into Ponyville safety? Will the unknown finally be explained? Find out reading this sequel to Not another Magical Mystery Mess!