When one of Twilight Sparkle's studies goes horribly wrong, she and Spike are sent to Earth, and quickly learn about what it's like to be aliens in a new world. With the help of a trio of humans, can they find a way back to Equestria?

Join the Southern truck driver Justin Daniels, and his two best friends; the self-proclaimed "Asian American Doctor and King of Hip-Hop", Carlos Wilkinson, and the "Blonde Brainiac Girl With a Plan", Ashley Sanderson, as they go on a journey across the state to help Twilight Sparkle and her number one assistant Spike safely return to their world.

When the government is after this world's otherworldly neighbors, however, this may prove to be quite the road trip for our group of "heroes"!