After things began to settle down in Ponyville the mane six began to find themselves settling down into a domestic life. Pinkie-Pie opened her own party shop, Fluttershy began to go professional with her animal talents, Rarity moved part-time in Canterlot, Rainbow Dash became a Wonderbolt, and Twilight Sparkle settled into her role as the Princess of Friendship. Life seemed to settle for the mane six.

Spike and Rarity's younger sister, Sweetie Belle, have grown closer. Now in a exclusive relationship Spike has gotten more possessive over the young mare. Spike's possessiveness over Sweetie Belle is concerning Twilight, so Twilight turns to books to understand why this is happening. It all comes to a head when Spike nearly kills a Pony when he was out with Sweetie Belle. Seeing this Twilight decides he needs to get out of Ponyville. So with Spike and Sweetie Belle in tow she sets off on an adventure across Equestria.