Its only been five decades since the White Mesa Research Facility went online, and it has changed the world. New advances in medical science allows far more lives to be saved. Instant communication has brought the world together. New weapons enabled the world to exterminate the changeling menace, once and for all. A golden age for the world dawns.

All this was possible only through the study of the human world. But no one has prepared for any possible unforeseen consequences or problems.

On a otherwise normal workday, the facility, and the world, will learn exactly why they should have prepared.