My Uncle Brixxi Returns follows a chubby mare named Elise Adler. She has been backstabbed by the Hitman she hired and had served only a year in prison before being bailed out. Brixxi takes Adler out to fix things between them, and eventually does so through the influence of three stallions, including himself. After her day of fun, she wakes up in a foreign location. The story takes place somewhere during Season 5 and before Adler ends up somewhere she doesn't recognize.