A mysterious disease has been spreading all over Equestria turning all kinds of ponies into brain-eating zombies. The disease has reached all over Equestria and threatens to wipe out the pony race. The pony gang, along with the help of Spike, Shining Armor, and Princess Luna, try to figure out how to stop the disease before it's too late. But with friends dropping like flies on either side, will they make it in time?