Twilight Sparkle and her friend's lives are put in danger when one of Zecora's potions is accidentally spilled into a batch of cupcakes. The disease spreads around Ponyville and ponies are eliminated, one by one. The last ten survivors (Twilight Sparkle, Big Macintosh, Applejack, Apple Bloom, Fluttershy, Lyra Heartstrings, Derpy Hooves, Trixie, Rarity, and Rainbow Dash) are all crammed in Applejack's barn with no escape.

Now, they have to live with each other in the barn and fight off hoards of deadly zombie ponies. If any of them make one little mistake, they could all end up dying slow and painful deaths.

WARNING: Descriptive violence.