(Dedicated in loving memory of Stan "The Man" Lee, co-creator of Spider Man, 1922-2018. Takes place in an alternative universe post Season 5.)

Hold onto your hooves, true believers! Spider Mare is back once again, and this time she's bringing along her new crime fighting partner, Black Cat.

A new crime syndicate is making a name for itself in Ponyville and all across Equestria, but authorities are puzzled by the mysterious nature of the criminals and their unknown leader. Spidey and Black Cat investigate, but even they have no clue who or what they're up against.

Meanwhile, from the shadows emerges an even greater threat than a crime syndicate. Four of the web slinger's greatest enemies are freed during a prisoner transfer and brought before two more villains with an ax to grind against our web slinging, crime fighting duo.

All the while, Pinkie Pie is distracted not just by her new relationship with Cheese Sandwich, but also by the boss for her Aunt Suzanne's new job at a local homeless shelter. Little does she know that said boss harbors a dark secret. One that will unleash perhaps her greatest arch-enemy yet.