Equestria has fallen to a plague, a plague of rampant death where the ones who die refuse to stay down. The corpses instead seeking out the warmth of the living with their only desire being to end it.

Twilight Sparkle is the final survivor of Ponyville's total infection. When her resources run low she manages to escape town, but not before falling ill to the sickness as well. As her vision begins to fade, her legs to weak to keep her standing, the mare sees a shooting star streak across the sky. With little hope in her body the mare makes a wish, a wish for someone to end this plague.