Twilight Sparkle wakes up and sees Ponyville exterminated including her friends. However, Derpy shows up at the marketplace and explains to Twilight that she serves Queen Glamour, who is imprisoned and that Twilight needs to think more critically. After Derpy somehow resurrects all of Ponyville (and many apologies and a little sleuth work) They discover Trixie was behind the murders and detonated a gamma bomb in the name of Discord who gave her the Element of Banality. Another mystery that Derpy hinted at. Now the Mane 6 need to stop Trixie and any other minion of Discord before all of Equestria is taken over. Granted with With radiated animals surrounding the wilderness and active plutonium deposits all around the countryside, they must be double careful