The two best party ponies in town, Pinkie Pie and Cheese Sandwich, have made their relationship official with a fun-tastic wedding! Everything seems to go well, until the Honeymoon phase passes and real adult life begins. The curly haired ponies decide they're ready for a foal, and do all they can to make this dream come true! Unfortunately, things start to go downhill during the pregnancy, and Pinkie Pie's mental illnesses get out of hoof. Cheese Sandwich has to deal with fatherhood and a troubled wife, all while having some mental issues of his own.