Mystic-Equestria Alliance began to fracture and may ignite the civil war. Mane Six and Dragon Strike Force open the School of Friendship for both ponies and creatures to learn and study 'The Magic of Friendship', and also proved that friendship is magical and powerful for everyone.

* Subplot #1: Demon Successors planned to bring Demon Lords back to the Mortal Realm and launched the invasion on its land! Team Fighters must prevent and defeat the Demons before they could achieve it.
* Subplot #2: Student Seven (Sandbar, Ocellus, Gallus, Silverstream, Yona, Smolder, Melody Bubbles) and the Rescue Warriors Club (Heatwave, Ciel, Kindy Dragoon, Aero & Rak, Solflare, Mano Telekinetic, D.E.C.K., Blackwitch, Bella Anime, Eve, Leo Chi & Jesuits Omnicron) must learn and work together to understand the means of friendship.