The Mane five have been having these awful dreams where they abandon this strange creature and leave her crying, their cutie marks start glowing and they visit Twilight to ask what is going on, they find her in the library preparing to leave on a trip. She explains to them what is going on and they noticed similarities between Anon-A-Miss and what happened at Cadance's wedding, as Twilight prepares to leave, a very sick Spike stumbles in, and Twilight immediately goes to him and diagnosed him with a unicorn illness. With her being the only one to treat it it is up to her friends to help Sunset and save the Rainbooms friendship.