When brothers, Iron Heart and Searing Arrow, are fleeing from their settlement. Searing Arrow gets caught by a group of raiders, and infected with the Blood Hoof Plague. After symptoms subtly start to show, the two brothers go on an journey to find a cure that is held within a stable. However, they will not be alone! With friends like the lovable and compassionate bat pony, Stacked Chip. The deadly and dangerous dragon, Fang, and more allies that they will make along the way.

However, the brothers will also make great and dangerous enemies, like Axe-Stone Blitz and Wildcard

They shall also come across memory orbs, that hold the memories of Twilight Sparkle, Rarity, Fluttershy, Applejack, Rainbow Dash and even Babs Seed, their grandmother. All of which will give the brothers and their allies, a better understanding of friendship.

The brothers and their allies will need to gather their strengths, weaknesses, skills and perks, to survive the Equestrian Wastes. As well as to find the cure to end the Blood Hoof Plague, once and for all!