Spike Williams along with his family and friends go to an island resort for summer vacation. But overnight however, a mysterious plague swept the island and turned everyone into ravaging mutants. Spike gets separated from his loved ones and quickly finds out that he’s somehow immune.

He later runs into a group of mutated girls who have managed to keep their sentience. Spike must work together with these girls if he has any chance of figuring out where this plague came from, finding his loved ones, and hopefully get out of the island alive.

Set in an alternate universe where humans and anthros live together.

Based loosely on Dead Island, Prototype, and Days Gone.