The Mane Six and Spike, along with the Young Six and the Cutie Mark Crusaders. return to Hogwarts School of Witchcraft and Wizardry for a second year of schooling. They will reunite once more with Harry Potter, Ron Weasley, and Hermione Granger for an epic and mysterious quest as the students of Hogwarts are being petrified. Many believe the answer to this mystery lies within a long dormant chamber hidden beneath Hogwarts known as the Chamber of Secrets.

Along the way, they shall reunite with many old faces, encounter many dangerous obstacles, and uncover many shocking secrets from both the Wizarding World and Equestria.