Dear Princess Celestia

"Spike. Stop making this so difficult! Just eat the food and try to get better, I cannot keep holding you in that cage! It's...Horrible, you don't deserve than when I can find a way to cure you!" Twilight begged with her voice echoing from desperation and the possibility that she may somehow fail to save her number one assistant, her magic was pushing a plate towards the cage holding Spike, Spike however remained unphased with his pupils expanding as he stared at Twilight with increasing concentration. "Spike! You can't just stare at me! You need to eat! I thought you ate meat! That's meat! So eat!" Twilight yelled out with her eyes filling with tears, her emotional tirade was momentarily silenced as she sensed the approaching power of Celestia's magic so she turned only to see a scroll materialising from a wisp of Celestia's solar magic, "Another letter. It would be nice if you'd use your powers and come see me yourself, Celestia. But that would mean getting in harms way." Twilight thought to herself as she levitates the scroll off the ground, Twilight pulled the seal away using her telekinesis and tossed it aside so she could unroll the scroll making her eyes momentarily pause when she began reading through the contents of the scroll.

"Oh now you believe me?! Ugh, well at least Canterlot is safe, hopefully. But how could this make up come out without Celestia being aware? Surely somepony as social as Celestia would require something like make up when constantly being around ponies." Twilight mumbled to herself as she placed the scroll down onto the nearby desk, her eyes were darting around the room as she questioned the unusual state of the situation then she turns to the stairs leading up to the castle. "Protect any uninfected ponies? I can handle that. First, letters for my friends. They need some more context on the situation" Twilight thought to herself as she galloped over to her desk, Twilight lifts a single quill off her desk so she could pull a nearby paper infront of her which she began writing on quickly.

Dear friends

I know this letter is not bringing or instilling much confidence, I must ask you listen to everything I am writing here on this letter.
Ponyville is in danger, there is an unusual sickness spreading that is causing ponies to heavily change, Spike is suffering from this sickness and I am alerting you, you must come to my castle at once so you can be kept safe for the length that this sickness is active.
I do not know how long Ponyville has left before the sickness begins spreading to other kingdoms or somewhere like Canterlot, I was informed by Princess Celestia that she is not aware of any infection there, please come to my castle as soon as you can before the situation grows anymore uncontrolled!

I have more than enough space for dozens of ponies in the entirety of Ponyville, I even have more than enough food to last us months due to Starlight's concern about requiring as much brain food for her studies.
I am awaiting your response, please use the spell I will be marking on the bottom of the scroll to send it back with a written response, I hope all is well for you my friends

-Sincerely, Twilight Sparkle

Twilight stared at the scroll with her eyes already filling with tears, "This is completely crazy, this can't be real." Twilight spoke softly as she covered her face with her hooves, she paused when she heard the sound of claws scraping against metal so she turned to see Spike had slightly shifted in his place so he was grabbing the bars of his cage. Twilight stared into the black voids that were slowly overtaking Spike's eyes until she felt herself suddenly beginning to move which forced her to turn her had away, "Get a hold of yourself Twilight. Your friends need you. Equestria might need you again." Twilight growled out as she bashed her hooves against her own face, Twilight felt the ache from her hooves colliding with her face until she lowered her forelegs and glanced towards the unsent scroll laying on her desk. Twilight narrowed her eyes as her violet magic lifts the scroll off the table then she struck the scroll with a bolt of similarly coloured violet magic that expanded outwards, Twilight squints her eyes as the scroll multiplied itself into five perfect copies of the original scroll that she had written.

"Hopefully my friends are okay, maybe they're not infected, maybe they're just...Hiding? Staying out of the way?..." Twilight spoke quietly as if attempting to convince herself more than trying to convince anypony else in her environment of such a possibility, Twilight shook her head and zaps each of the scrolls with her personal transmission spell reducing all five of them into wisps of violet coloured magic. Twilight flicks her head towards the doorway making all five wisps float their way out through the staircase until they disappeared from Twilight view, Twilight was left in silence until she let out a breath she hadn't even realized she had been holding so she glanced towards Spike. Spike was still staring towards her with his eyes seeming to have slightly changed to express some undeniable degree of anger or discomfort at the situation, "Oh don't look at me like that. You're the one who won't look away from me." Twilight spoke out with her eyes narrowed, she then trots over to the staircase with her wings momentarily unfurling until she had disappeared from the room, Spike was left in silence as his claws scraped against the bars with the metal slowly getting cut as he clenched his fingers around the bars.