It's been one hundred and twenty-six years since Twilight Sparkle developed the Enhancement process from the ancient codices of Starswirl the Bearded. One hundred and twenty-six years of death, pain, and destruction as Twilight's abominations have gone horrendously mad, wreaking carnage beyond comprehension.

And now she's the only pony--only being--left.

Written by suggestion of NaughtSought as a Thirty Minute fic.
Contains speculative, yet plausible science-fiction concepts.
One-shot.
Based on the following short story (The World's Shortest Horror Story):
"The last man on Earth sat in his room. There was a knock on the door."
--Anonymous