For decades, Victor von Doom has waged an endless campaign to take Earth in his iron grip. Every time he has victory within his grasp, however, the accursed Fantastic Four snatch it away from him. During one battle in the Negative Zone, Doom is lost in the void and assumed dead.

Little do the heroes of Earth realize that Doom is still alive, having found himself on a new world. Setting up a new base, Doom uses his advanced technology, devious intellect, and skills in the dark arts to impose his will on the land of Equestria.