Derpy Hooves is just the local mailmare whom everyone tries to stay out of the way of, because they hate ponies who are ‘different’….and she is different, due to an accident she had when she was young.
But when a bumbling, geeky stallion called the Doctor arrives in Ponyville, he takes a special interest in Derpy when she stands up to an angry manticore in order to save the lives of the schoolchildren. Impressed with her skills and compassion, he decides to take her on wonderful adventures, only to come to a planet that has the most deadly aliens in the universe. When Derpy almost dies, the Doctor takes her back home and leaves her alone, leaving her to a life of uncomfortable attention focused on her, and after a while, both miss each other desperately and come back together in their friendship, only to realize they are in the greatest danger they have ever faced....