As the Ponytech was trying to create a type of pesticide to destroy the demons that have been attacking Equestria, something goes horribly wrong. A mutation chemical poured into it, making demon reaction positive and to mutate ponies and make dangerous creatures. As they spray it in the air, the ponies 'evolve' and harmless Everfree creatures are turned into super-mutants. Will the mane 6 be able to handle it this time?