The Doctor is in trouble and it’s up to Twilight to help. Instructions on what to do are written in his Diary, but the text scrambles itself to hide it’s secrets. So with no other clear options, she decides to read from page one.

After the escape at Aperture Science, Mel is swept away into Equestria,

The last few humans on Earth, a small group of Teenagers undergo a tough life of the world collapsing around them. But they decide that if they want to survive, ponification is the key.

The Doctor has accidentally crashed into the world of Equestria and needs to recover the fragments of the boundries between their two universes.

The three older actors playing the Doctor discover that there's going to be a 50th anniversary special.