For three millennia the Terrans have kept their existence hidden from the ponies of Equestria. Now they are forced to recognize that the ponies may have become a threat to the Terran nation once again.

Shepard and Anderson are tossed into Equestria shortly following the activation of the Crucible super-weapon. Once there, they meet a tribe of buffalo who seem to know exactly who Shepard is.

Isaac Clarke fights necromorphs in Equestria. MLP crossover with Dead Space