When Rainbow Dash's sudden illness seems to be too much for Equestria's best Doctors, Twilight summons the Princeton-Plainsboro Teaching Hospital Team in a fit of rage. Now House, Wilson, Cuddy Chase, Taub, Foreman, and Thirteen must get to the bottom of this new case in a new world. And the solution will prove both surprising and saddling. But ultimately leads Wilson to confront House about what being a true friend really is.