In the far future, ponykind has left the reaches of Equestria and expanded towards the stars. Under the leadership of Captain Sparkle the spaceship Harmony is travelling into the unknown depths of the universe. Alongside her faithful crew they are exploring the seemingly infinite space, seeking to discover the last secrets of the universe.

The greatest secret however is how they even got this far without blowing up.

Star Trek parody. Twilight is still a unicorn in this story.