Canterlot High is going through a craze from the Far East, that craze is Duel Monsters and everyone is getting into the Game. but not all is fun as a mysterious boy is calling for a war against 'The Evils of Friendship' and vows to defeat all against him, mainly his hated enemies: Yugi Moto from Japan and the Mane 7. While another duelist is seeking to stop it from happening

But even as this is happening, a new threat grows as an evil warlord seeks to finish was the Atlantian King Dartz started, this time using the Power of the Orichalcos and the Shadow Realm.

It is time for The Equestria Girls to get their Game on!