My Little Diseases

Celestia finally stirred… Lifting her aching head to survey her surroundings. She was in a stone cell, the barns of the door were thick metal, the gps too small to fit through. She attempted to cast a teleportation spell, but seiring pain raced through her head. She brought her hoof to her forehead only to feel that her horn had been broken off. Old blood trails stain her face from where her horn was severed.

Celestia gave a soft sigh, her eyes going glossy, but she tried to remain strong as she looked down at herself. She noticed her back was bare, no wings to be seen. Her mane had also been cut short to the point of nearly being bald, her tail had been given the same treatment.

She slowly stood. At least she had range of motion in her legs… She looked around her cell, and saw a strange movement in the corner of her cell, slowly moving toward it. She saw it was Flim and Flam, still fused together as a giant blob. The salesman twins look at Celestia slowly, giving gargled groans and moans. The sun princess rapidly backed away from Flimand Flam in shock, her rump bumping into the wall behind her.

“Well well well…” A familiar voice echoed through the basement, catching Celestia's attention. Looking out of her cell, she saw Twilight.
“I see you’ve met my little friend.”
Twilight continues, smirking as she looks at Flim and Flam, looking almost proud of what she’s done.

“Let me get you up to speed with those 2. Flim and Flam were injected with my hoof-made illness ‘Together Forever syndrome’ that forces 2 ponies together and become one. They should have died many moons ago. But either their bodies evolved rapidly to get used to this new way of life, or the infection isn't as fatal as I originally thought.”

Twilight explained, walking over to the door of the cell and tapping on the wall to get Flim and Flam’s attention. The giant blob slithered over, leaving what looked like a shimmering trail behind them, that akin to a snail.

She pulls out 2 freshly picked apples, using her magic to pull them in half, before feeding them to Flim and Flam. The 4 halves slowly absorbed into their bodies, dissolving upon contact, as if their skin was one big digestive system.
Celestia only recoiled in disgust as she watched this all unfold in front of her, looking at Twilight with her ears folding flat against her head.

“Twilight. I demand you release me. I have a duty to uphold, as does my sister.”
Celestia barked, her tone authoritative.
But Twilight simply laughed at Celestia’s demand, slowly pacing in front of the cell door.

“Do you REALLY think you're in ANY position to give demands?”
Twilight asked.
“Besides, you don't need to worry about your sister, she’s safe too.”

As she says this, Celestia sees Pinkie Pie entering the basement with a small basket resting across her back, she used a key to open the door of a neighbouring cell, only to reveal Princess Luna, sitting in the middle of her cell, her horn and wings were also severed, but her mane and tail remained. Her eyes were wide and her body remained still to any kind of outward stimulation. The only time she moved was when Pinkie Pie held a carrot under Luna's nose, which she promptly began to eat, before returning to her original position.

Her sclera were made up of many colours now, and she had the same, random colours layered over her eyes and muzzle. She had been infected with ‘Manic Colour Syndrome’ the same infection Rainbow Dash had.

“She made a wonderful test subject for ‘Manic colour Syndrome’. Given how our previous test subject sadly passed before we came up with any definitive cure, and there's only so much tissue sample you can get from an imploded body.”
Twilight recalled, giving a soft chuckle before moving to one of the many, messy and unorganised lab tables, picking up a trophy.

“I will say though, with all our breakthroughs, we’ve been deemed the healthiest state in Equestria! You should have come to that Party Celestia. It was amazing! As for the cures I mentioned. The one for the flesh eating virus and flightless bird syndrome, those vaccinations have finally been distributed throughout Equestria. And i'm very proud of how far my love and I have come.”
As she says this, she gives a loving smile to Pinkie.

“If you’ve been deemed so safe, then you shouldn't need to test more infections! You have all the safety you need! Just release me and my sister!”
Celestia demanded once more, attempting to reason with her former student.
But Twilight simply chuckled again, turning to Celestia.

“Even if I wanted to help you, you’re already too far gone.”
Twilight responded maliciously, before pointing to Celestia’s stomach. Celestia looked down, to see her stomach was covered in faint, black spots from the very infection, Celestia tried to hide away, the Unseen Blight.

“While I won't be able to monitor the progress of the infection given how the horn and wings are gone, it’ll be interesting to see how it affects an alicorn once it reaches its final stages.”
Twilight explained to a very confused Sun Princess.

“But… You vaccinated me… I'm safe from this, how am I infected?”
Celestia frantically asked, her ears folding back and her eyes wide, to which twilight’s manic smile grew wider across her cheeks, her ear giving a small twitch and her pupils shrank to pinpricks.

“Well, it's simple. Your vaccination was fake. I gave you a simple vaccination for the feather flu, while everyone else got the Unseen Blight vaccination. I've been ITCHING to get you to feel how i felt, when i was infected. The fear, the loneliness, the sense of dread. You sent your SISTER, to save me, when I needed you most. Now you get to experience, first hoof, how i felt, while i was praying for you to come and help me.”

Twilight then raised her hoof, to prevent Celestia from responding, before she continued to speak.
“Don't get me wrong, I'm eternally grateful for what Luna has done to help me. She saved my life, as did my best friend.”
Twilight pointed to her white horn.

“But I'm not about to forget what’s been lost, because you were ‘too busy’ to come and help me. And sent Luna, like she didn't have her own duties to attend to.”
As Twilight spoke, she continued to pace in front of Celestia’s cell door, her eyes locked on the former princess, as she watched the spots begin to grow slowly.

Celestia doubled over in pain as the spots grew wider, stretching her skin to accommodate the amount of liquid building up in them.
Pinkie locked Luna’s cell door and walked over to stand beside Twilight, as they watched the white pony writhe in agony from the rapidly growing lumps on her torso.

Twilight and Pinkie looked at each other with a smirk, before they began to laugh, and laugh… and laugh…

The end…?

Epilogue
Twilight shoved a soggy mop onto the ground, mopping up what was left of Applejack’s corpse. While she was cleaning, Pinkie Pie was testing vials of cures for Manic Colour Syndrome.
“Say.. Twilight?”
Pinkie spoke up. Catching the purple alicorn’s attention.

“I think there may be more infections that you can make, that may be…. Entertaining to work on. Maybe we can find other species… Like a griffin or a dragon..”
Pinkie suggested as she mixed some samples together.

“I suppose we can do that.”
Twilight responded before she returned to mopping the ground.

“What about them?”
Pinkie Pie asked, pointing toward… you.

“Who?”
Twilight asked.

“Them! The ones who have been watching our every move since our journey began! Do you think they’ll like our next experiments together?”
Pinkie asked again, looking toward you, giving you a wink. Twilight simply rolled her eyes with a smile, and continued to clean up the mess.