When a Combine teleporter prototype goes haywire at Nova Prospect, a four member fireteam from Combine Overwatch get some visitors from Equestria and get a second chance of living normal lives once again.

A sickness breaks out on the Eastern Coast of the United States of America when a biological weapon goes off during transport, and slowly spreads across the world. Along with the newly introduced pony country, the United States of Equestria.