Set in an alternate future where a fungal infection threatens to be the end of Equestria, a mare, hardened by years of brutal survival in an unforgiving apocalyptic world, must learn to let go of her past and move on in order to smuggle the most dangerous, and bizarre, cargo of her life.

Along the way of completing the delivery, the mare finds herself losing old friends, gaining unlikely new ones, confronting enemies of new and old, and forging an unbreakable bond with the one pony she thought she despised the most.